A Review on Some Natural Biopolymers and Their Applications in Angiogenesis and Tissue Engineering

Document Type : Review Article


1 Department of Tissue Engineering, Faculty of Advanced Technologies, Shahrekord University of Medical Sciences, Shahrekord, Iran

2 Department of Emergency Medicine, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran

3 Department of Molecular Medicine and Genetics, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran

4 Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran

5 Department of Tissue Engineering and Biomaterials, School of Advanced Medical Sciences and Technologies, Hamadan University of Medical Sciences, Hamadan, Iran


One of the concerning challenges for engineering and regenerating tissues is providing a suitable condition for development of a utilitarian vascular matrix. Natural polymers such as collagen, gelatin, chitosan, silk fibroin and fibrin are used as bio-compatible scaffolds to prepare appropriate biological and mechanical conditions for regenerative medicine and tissue engineering approaches. A wide range of studies demonstrated that using these biomaterials as scaffolds or engineered constructions such as hydrogels can provide a microenvironment to improve regeneration and repair of target tissues and organs through enhancing angiogenesis. They can be used single or in composition with each other. This review focused on some different natural polymeric constructs that have been incorporated in tissue engineering.


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