Evaluation of Effectiveness of Honey-Based Alginate Hydrogel on Wound Healing in Rat Model

Document Type : Original Article


1 Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran

2 Biotechnology Research Center (BRC), Pasteur Institute of Iran, Tehran, Iran


Alginate hydrogel and honey have a notably effect on wound healing process, therefore assessment of combined impact of those are essential. In this study, the effect of honey-based alginate hydrogel, alginate hydrogel and commercial alginate dressings in recovery of wound in a rat model was studied. In this study, 20Wistar rats were divided into four groups of five. One wound of 1×1 cm square was marked using a template and the skin, on either side of the vertebral column between the ears, excised. One of the rats in each group was euthanized on the 4th, 7th, 14th, and 21th days and skin samples were taken for histopathological analysis. Findings showed that the average total time of wound healing in group of treated with honey-based alginate hydrogel dressing was the best treatment as opposed to the other groups. With respect to all information obtained of the study we found that the honey-based alginate hydrogel is much convenient for wound dressing and treatment of surface wounds. Therefore, outcomes of the treatment make our dressing highly promising as an alternative wound healing system for the treatment of wounds and certainly opening new path for future research and development.