The Relationship between the Presence of Enterotoxin Type B Gene and Antibiotic Resistance in Staphylococcus aureus

Document Type : Original Article


1 Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran

2 Department of Medicine, Faculty of Medicine University Kebangsaan Malaysia, Kuala lumpour, Malaysi


Staphylococcus aureus is a hazard to human health since they can cause a wide variety of hospital-associated infections ranging from minor skin infections to post-operative wound infections and food poisoning which produces many different virulence factors, including enterotoxins (SEs). Although  studies  have  been  done  regarding  the difference  between  virulence  factors  of  sensitive strains and resistant to antibiotics, the aim  of this study was to investigate this topic in different patients. This cross-sectional study was performed on 100 patients admitted to a hospital in Tehran. After preparing of wounds samples, antibiogram study was done by disc diffusion method and prevalence of staphylococcal enterotoxin type B or seb gene was confirmed by Polymerase Chain Reaction. Data was analyzed using SPSS 17 software. Results showed that the highest percentage of isolates with positive seb gene is about 7% which related to amoxicillin (6.6%), penicilline and cotrimoxazole (6.5%). More than 90% of isolate are resistant to amoxicillin, penicillin and cotrimoxazol. According to results, a significant relationship between seb gene and resistance to related antibiotics was not observed.