Growth factor Containing Hydrogels for Tissue Engineering Applications

Document Type : Review Article


1 Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran

2 Department of Stem Cells and Developmental Biology at Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran

3 Department of Metallurgy and Materials Engineering, Faculty of Engineering, University of Semnan, Semnan, Iran

4 Department of Biomaterials, Science and Research Branch, Islamic Azad University, Yazd, Iran

5 Department of biomaterials, Science and Research Branch, Islamic Azad University, Yazd, Iran


Regenerative medicine provides substitutes for organ transplantation, which is restricted in applicability due to immune responses against allograft and the large discrepancy between the need for organs and the number of available transplantation. An artificial environment is allowing cells to induce tissue regeneration. Growth factors (GFs) play a significant role in the cell fates in their microenvironment. Nevertheless, the short half-lives of GFs and poor in vivo stability infiltration suggest that the classical routes are useless and insist on use of a drug delivery system (DDS). In this review paper, growth factor-based tissue regeneration using polymeric hydrogels is reviewed to show great potential ability of hydrogels in tissue engineering (TE).