Journal of Applied Biotechnology Reports

Journal of Applied Biotechnology Reports

Electrochemical Determination of Calcium Dobesilate on Graphene Glassy Carbon Modified Electrode

Document Type : Original Article

Authors
Maryam Iman 1
Fariba Dashtestani 2
Zahra Zafari 3
Mehdi Kamali 4
Manizheh Ramezani 4
Khadijeh Eskandari 4
1 Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
2 Institute of Biochemistry & Biophysics, University of Tehran, Iran
3 Department of Energy Engineering and Physics, Faculty of Physics, Amirkabir University of Technology, Tehran, Iran
4 Nanobiotechnology Research Center, Baqiyatallah University of Medical Science, Tehran, Iran
Abstract
Graphene modified glassy carbon electrodes have been developed for the determination of calcium dobesilate in pharmaceutical formulations. The prepared graphene and CNTs were used as a conductive substrate for electrochemical study of calcium dobesilate. The direct electrochemistry of calcium dobesilate showed a reversible cyclic voltammogram with a formal potential of 133 mV (vs. Ag/AgCl) for graphene modified electrodes in 0.1 M phosphate buffer. The linear concentration range of the sensor is 30-120 ng/mL for graphene modified electrode, respectively. The lifetime of biosensor is more than 2 weeks. The proposed modified electrode provides a new promising and alternative way to detect calcium dobesilate
Keywords
graphene
Sensor
Direct Electrochemistry
Calcium Dobesilate
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Journal of Applied Biotechnology Reports
Volume 3, Issue 1
Winter 2016
Pages 373-375

  • Receive Date 12 January 2017
  • Revise Date 12 February 2017
  • Accept Date 12 February 2017