Antibacterial Behavior of Oxygen-Generating Nanomaterial for Medical Applications

Faraji, Mehdi; Mohammadzadeh, Fatemeh; Sanjabi, Kimia; Saraei, Mohadese; Gholipourmalekabadi, Mazaher

doi:10.30491/jabr.2025.560642.1949

Antibacterial Behavior of Oxygen-Generating Nanomaterial for Medical Applications

Document Type : Review Article

Authors

Mehdi Faraji ¹

Fatemeh Mohammadzadeh ²^{, 3}

Kimia Sanjabi ²^{, 3}

Mohadese Saraei ²^{, 3}

Mazaher Gholipourmalekabadi ²^{, 3}^{, 4}

¹ Oral and Maxillofacial Surgery Resident, Craniomaxillofacial Research Center, Oral and Maxillofacial Surgery Department, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran

² Stem Cell and Regenerative Medicine Research Center, Iran University of Medical Sciences, Tehran, Iran

³ Department of Medical Biotechnology, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran

⁴ Nanobiotechnology & Regenerative Medicine Innovation Group, Noavarn Salamat Zhino (Zhinohealth), Tehran, Iran

10.30491/jabr.2025.560642.1949

Abstract

There are significant challenges for the development of an efficient antibacterial agent for the prevention or treatment of post-surgical infections, especially with synthetic scaffolds for surgical implants. This problem has been further exacerbated by the extensive use of antibiotics in healthcare settings, which has led to an increased incidence of multidrug-resistant bacteria. Despite several successes in developing novel antibacterial agents, there are ongoing efforts to find effective and safe ones. Recently, the development of oxygen-generating nanomaterials has been proposed as a promising approach for antibacterial applications. The preliminary investigation demonstrated that such materials could exhibit strong antibacterial activity, minimize postsurgery-induced hypoxia, and prevent infections. Regenerative medicine is a multibillion-dollar industry, and the lack of suitable materials, such as 3D scaffolds, has hindered its application in clinical settings. A critical review of the different kinds of oxygen-generating reagents, as well as their mechanisms of oxygen release and antimicrobial potential, is presented, following an appraisal of the literature.

Keywords

Antibacterial Agents

Nosocomial Infections

Post-Surgical Infections

Oxygen-Generating Biomaterials