Journal of Applied Biotechnology Reports

Journal of Applied Biotechnology Reports

Antibacterial Behavior of Oxygen-Generating Manomaterial for Medical Applications

Articles in Press

Document Type : Review Article

Authors
Mehdi Faraji 1
Fatemeh Mohammadzadeh 2, 3
Kimia Sanjabi 2, 3
Mohadese Saraei 2, 3
Mazaher Gholipourmalekabadi 2, 3, 4
1 Oral and Maxillofacial Surgery Resident, Craniomaxillofacial Research Center, Oral and Maxillofacial Surgery Department, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran
2 Stem Cell and Regenerative Medicine Research Center, Iran University of Medical Sciences, Tehran, Iran
3 Department of Medical Biotechnology, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran
4 Nanobiotechnology & Regenerative Medicine Innovation Group, Noavarn Salamat Zhino (Zhinohealth), Tehran, Iran
10.30491/jabr.2025.560642.1949
Abstract
There are significant challenges for the development of an efficient antibacterial agent for the prevention or treatment of post-surgical infections, especially with synthetic scaffolds for surgical implants. This problem has been further exacerbated by the extensive use of antibiotics in healthcare settings, which has led to an increased incidence of multidrug-resistant bacteria. Despite several successes in the development of novel antibacterial agents, there are ongoing efforts to find effective and safe antibacterial agents. Recently, the development of oxygen-generating nanomaterials has been proposed as a possible choice for antibacterial materials. The preliminary investigation demonstrated that such materials could exhibit strong antibacterial activity, minimize postsurgery-induced hypoxia, and prevent infections. Regenerative medicine is a multibillion-dollar industry, and the lack of suitable materials as 3D scaffolds has hindered its application in clinical settings. A critical review of the different kinds of oxygen-generating reagents, as well as their mechanisms of oxygen release and antimicrobial potential, is presented, following an appraisal of the literature.
Keywords
Antibacterial Agents
Nosocomial Infections
Post-Surgical Infections
Oxygen-Generating Biomaterials
Journal of Applied Biotechnology Reports

Articles in Press, Accepted Manuscript
Available Online from 14 June 2026

  • Receive Date 21 November 2025
  • Revise Date 30 December 2025
  • Accept Date 30 December 2025