Prognostic Value of Combined SATB2 and Ki67 Expression in Colorectal Cancer Patients: A Retrospective Cohort Study

Kareem. Leelo Al-Obaidy, Abdulameer; A. Kareem, Hawraa; Jabbar Hasan, Yusra

doi:10.30491/jabr.2025.512767.1855

Prognostic Value of Combined SATB2 and Ki67 Expression in Colorectal Cancer Patients: A Retrospective Cohort Study

Document Type : Original Article

Authors

Abdulameer Kareem. Leelo Al-Obaidy ¹

Hawraa A. Kareem ²

Yusra Jabbar Hasan ²

¹ Department of Basic Medical Science, Nursing College, University of Al-Qadisiyah, Diwaniyah, Iraq

² Department of Al-Jawad Oncology Center, Al-Emamain Al-Kadimain Medical City, Ministry of Health of Iraq, Baghdad, Iraq

10.30491/jabr.2025.512767.1855

Abstract

Introduction: Colorectal cancer is the third most prevalent malignancy, with limited prognostic tools due to its heterogeneity. This study examined the simultaneous expression of SATB2 and Ki67 in colorectal cancer patients by immunohistochemistry, with progression-free survival (PFS) and patient demographics.
Materials and Methods: The study employed an observational cohort design with a cross-sectional approach, defined as a retrospective-prospective clinicopathological analysis of 128 colorectal cancer patients to examine SATB2/Ki67 immunoreactivity, including variables such as diagnosis duration, progression-free survival (PFS), age, sex, tumor location, grading, histopathological types, and TNM classification. Survival and ROC curve analysis tests were used to determine 46 months as the PFS cutoff and survival criterion.
Results: Fifty-six individuals survived PFS, while 72 did not. Patients averaged 54.45 years old, with a 22-67 months PFS, averaging 47 months. Colorectal tubular adenocarcinoma patients had the highest PFS; PFS was lower for rectal cancer patients. SATB2 expression exhibited no significant changes based on gender or patient age; however, female patients showed increased Ki67 expression compared to males. The average expressions of SATB2 and Ki67 were 40.21% ± 29.41% and 25.27% ± 23.16%, respectively. According to TNM staging, 68.9% of patients were categorized in stages I–II, 23.4% in stage III, and 7.8% in stage IV, with survival rates declining as tumor metastasis increased.
Conclusions: The study suggested that evaluating SATB2 expression during colorectal cancer treatment could clarify its prognostic importance. SATB2 expression correlates positively with colorectal cancer survival; nevertheless, elevated Ki67 levels negatively impact prognosis, particularly when SATB2 levels are high.

Keywords

SATB2

Ki67

Colorectal Cancer

Progression Free Survival

Immunohistochemistry