Regulatory Interplay of Long Non-Coding RNAs in Breast Cancer Progression

R, Vibhushini; Veerabhadran, Jyothishree; Veerabadran Ghone, Nalinkanth; Jayaraman, Hariharan

doi:10.30491/jabr.2024.470488.1762

Regulatory Interplay of Long Non-Coding RNAs in Breast Cancer Progression

Document Type : Review Article

Authors

Vibhushini R ¹

Jyothishree Veerabhadran ¹

Nalinkanth Veerabadran Ghone ²

Hariharan Jayaraman ¹

¹ Department of Biotechnology, Sri Venkateswara College of Engineering, Post Bag No.1, Sriperumbudur Taluk - 602117, Kancheepuram, Tamil Nadu, India

² Department of Chemical Engineering, Sri Sivasubramaniya Nadar College of Engineering, Rajiv Gandhi Salai (OMR), Kalavakkam - 603110, Tamil Nadu, India

10.30491/jabr.2024.470488.1762

Abstract

Globally, breast cancer is a severe and diverse disease with a high morbidity and death rate. Recent studies have highlighted the critical role of long non-coding RNAs (lncRNAs) play in the initiation and spread of breast cancer. lncRNAs are crucial regulators of gene expression and are implicated in various cellular processes, including tumorigenesis. The dysregulation of lncRNAs has been linked to aberrant cell proliferation in breast cancer. By modulating gene expression at transcriptional and post-transcriptional levels, lncRNAs can promote or suppress cell proliferation, influencing tumor growth and progression. lncRNAs can control the invasion and migration of breast cancer cells, thereby promoting the spread of metastatic cancer to other organs, through interactions with miRNAs and other molecular pathways. Understanding the intricate mechanisms by which lncRNAs contribute to these processes is essential for developing targeted therapies and improving patient outcomes. The crosstalk between lncRNAs and other intracellular proteins is important for understanding their functional roles in breast cancer progression. Protein interactions influence the stability, activity, and localization of lncRNAs, which in turn influences how these RNAs affect cellular processes. This review investigates the complex interactions of lncRNAs with miRNAs and proteins in breast cancer, with a focus on their roles in metastasis, proliferation, and other stages of the disease's progression. Moreover, with the ability to target specific genes, identifying novel biomarkers, therapeutic targets and potential in overcoming drug resistance lncRNAs represent an exciting area in RNA-based therapies and have the potential to transform breast cancer treatment.

Keywords

lncRNAs

Breast Cancer

miRNA

Cancer Pathways

Cancer Progression and Regulation