Synthetic Biology Approaches for the Production of Flavonoids

., Anushtha; Soni, Yachna; Choudhary, Harshita; Kumar, Kapila

doi:10.30491/jabr.2024.453340.1722

Synthetic Biology Approaches for the Production of Flavonoids

Document Type : Review Article

Authors

Anushtha .

Yachna Soni

Harshita Choudhary

Kapila Kumar

Department of Biotechnology, School of Engineering and Technology, Manav Rachna International Institute of Research and Studies, Faridabad, Haryana, India

10.30491/jabr.2024.453340.1722

Abstract

Flavonoids are phenolic carbon compounds, a class of plant secondary metabolites known for their unique properties such as antioxidant, antiinflammatory, coloring agent, and many more. Due to their diverse properties, they are being utilized in the industrial sector at a very high pace. The conventional methods are limited to low amounts of biomass from the source. Synthetic biology offers a promising approach for enhancing the bioproduction of flavonoids due to its tremendous advantages over conventional extraction methods. This review focuses on recent developments in applying synthetic biology techniques specifically towards microbial synthesis of flavonoids. It provides a comprehensive overview of the recent advancements in synthetic biology approaches to optimize microbial systems for efficient flavonoid production. Emphasizing genetic engineering, metabolic engineering, and systematic design principles, these techniques represent an immense shift in bioproduction strategies. The insights presented contribute significantly to our understanding of the effectiveness of these methodologies in the production of flavonoids.

Keywords

Pathway Engineering

Metabolic Engineering

Biological Engineering

Chassis

Biosynthesis