Efficacy and Adverse Effects of the Most Common COVID-19 Vaccines: a Rapid Review Study

Document Type : Review Article


1 Student Research Committee, Baqiyatallah University of Medical Sciences, Tehran, Iran

2 Baqiyatallah Research Center for Gastroenterology and Liver Diseases (BRCGL), Baqiyatallah University of Medical Sciences, Tehran, Iran

3 Department of Surgery, Trauma Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran


COVID-19 raised a flood of events all through the world in multiple fields. Reaching an agreement to generate and use vaccines against SARSCoV-2 (the cause of COVID-19) was likely the most controversial topic among different communities. Being new developed and lack of longitudinal characterization of these vaccines, the growing concerns were expectable. Now, regarding the conduction of large global studies, it is more possible to figure out the ambiguous characteristics of common anti-COVID-19 vaccines. The aim of the present study was to make a rapid overview on the efficacy and side effects of eight common COVID-19 vaccines used in Iran (Sinopharm, Oxford-AstraZeneca, BIV1-CovIran (COVIran Barekat), Pastocovac, Sputnik V, Covaxin (Bharat), Noora, and Pfizer-BioNTech). Using the designed search syntax, composed of MeSh terms, the published records were searched in PubMed database. The high-quality articles, meeting the inclusion criteria, were exploited to extract the interesting data. The final data pool, minded for all eight vaccines, was summarized, categorized, arranged, and presented separately. The trimmed findings demonstrated that all approved vaccines have several mild to moderate side effects. The final results of the present study depicted a big picture of commonly used vaccines and rapidly overviewed their efficacies and side effects.