Suppressing SARS-CoV2 Genome Replication: A Way to Overcome the Rate of Spread

Document Type : Review Article


1 Department of Virology, Iran University of Medical Sciences, Tehran, Iran

2 Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran


One of the main reasons for the high prevalence of SARS-CoV2 is the high speed of its replication and reproduction. The replication inhibitors are under investigation due to the importance of prevention of the spread of coronavirus disease 2019 (COVID-19). In coronavirus replication, the virus enters the cell by endocytosis. After uncoating, the positive-strand RNA is translated to produce the non-structural protein (NCP) precursors. These precursors are cleaved and form mature, functional helicase and RNA polymerase. A replication-transcription complex (RTC) is then formed. Targeting the various stages of this process may be useful in preventing the spread of this epidemic. According to the similarity of the COVID-19 replication to the other single-stranded RNA viruses such as HCV, Ebola Virus, and Marburg, the best way to prevent the spread of infection is the viral genome replication targeting with specific drugs after exposure to the virus. For COVID-19 medications, compounds that target SARS-CoV2 replication are being tested in silico, in vitro, or in vivo. According to other clinical trials that have been applied for SARS-CoV and MERS-CoV inhibitor drugs in the attachment, protease, and replication stages can prevent the virus from multiplying.  By reviewing previous related articles in this field, in this review article, we have tried to focus on all the information related to genome replication and categorize known drugs that have been applied as clinical trial treatments. The use of these drugs and other medications seems to be effective in reducing the prevalence of COVID-19.