The Effect of Probiotics Supplements on Oxidative Stress in Various Diseases: A Systematic Review Study

Mahmoudi, Sadrollah; Ghane, Mohammad Reza; Faraji, Mehrdad; Goodarzi, Hassan; Shahjooie, Fahimeh; Javadzadeh, Hamid Reza

doi:10.30491/jabr.2020.117863

The Effect of Probiotics Supplements on Oxidative Stress in Various Diseases: A Systematic Review Study

Document Type : Review Article

Authors

Sadrollah Mahmoudi

Mohammad Reza Ghane

Mehrdad Faraji

Hassan Goodarzi

Fahimeh Shahjooie

Hamid Reza Javadzadeh

Trauma Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran

10.30491/jabr.2020.117863

Abstract

Introduction: Recently, the consumption of probiotics to decrease Oxidative Stress (OS) has been recommended. The present study aimed to assess the effect of probiotics on OS in various diseases as well as in different models in a systematic review study.
Materials and Methods: Articles were searched through scientific sources such as PubMed, MEDLINE, Wiley, EMBASE, ISI Web of Knowledge, and Scopus by two review authors independently. The keywords that applied to search these articles included: Probiotics, OS, Stresses, Oxidative, and Stress. Results were then combined and reviewed regarding the type of study, type of disease/participants, and outcomes.
Results: In order to conduct this study, 19 eligible studies were investigated. The results showed that various probiotics supplements could improve OS parameters in pregnant women, patients with type 2 diabetics, Diabetic Kidney Disease (DKD) type 2, gestational diabetes mellitus, and the aging process, inflammatory factors in petrochemical workers, acute necrotizing pancreatitis, and polycystic ovary syndrome. However, no significant effect was reported on the oxidative status in patients with Rheumatoid Arthritis.
Conclusions: Probiotics supplements could improve OS biomarkers in various diseases. There are still some controversies about these methods and types of probiotics supplementations. It is recommended that more studies should be conducted for a better decision.

Keywords

Probiotics Supplements

Oxidative Stress

Diseases