Document Type : Review Article
National Institute of Genetic Engineering and Biotechnology Iran, Tehran
Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
Bacteria utilize a multitude of methods to secretion of specific substrate across phospholipid membranes. These bacterial strategies can play many roles in promoting bacterial process, from enhancing pathogenesis to bacterial response to environmental condition. The secretion in bacterial species transfer and release performance substance such as proteins, enzymes and metabolites to environment. The process of secretion plays an important role in the performance and compatibility with environment. Many bacteria use dedicated protein secretion systems to secrete from the cytosol into environment. In general, bacterial protein secretion systems classified to different classes, there are at least six specific secretory systems in Gram-negative bacteria. In this study, we review type I and II secretory systems of Gram-negative bacteria.