Neuroprotective Effect of Coenzyme Q10 in Hippocampal Injury in Balb/c Mouse

Document Type: Original Article

Authors

1 Department of Anatomy, School of Medicine, Iran University of Medical Science, Tehran, Iran

2 Department of Tissue Engineering, Tehran University of Medical Science, Tehran, Iran

3 Stem Cell Research Center & Department of Anatomy, School of Medicine, Hormozgan University of Medical Science, Bandar Abbas, Iran

4 Cellular and Molecular Research Center & Department of Anatomy, School of Medicine, Tehran University of Medical Science, Tehran, Iran

Abstract

Coenzyme Q10 is a promising agent for neuroprotection in neurodegenerative diseases. Neuroprotective effects of Coenzyme Q10 demonstrated in some neurodegenerative diseases such as Parkinson, Alzheimer and etc. Hippocampus is home of these diseases. We assayed Coenzyme Q10 effects on Hippocampal injury model and our hypothesis is that Coenzyme Q10 has Neuroprotective effects in some neurodegenerative diseases via hippocampus. For this purpose 24 Balb/c mouse took in 4 groups: Control (Without any treatment), Vehicle (Treated with sesame oil as Coenzyme Q10 vehicle), Hyppocampal injury model (Treated with Trimethyltin chlorideneurotoxin, 2.5 mg per kg IP), and test (Treated with Coenzyme Q10 after Trimethyltin chloride injection, 10 mg per kg IP for 2 weeks). After two weeks brain harvested and hippocampus tissue assayed by Nissl and Tunnel staining. Hystological study showed significantly increase of normal cells and decrease of apoptotic cells in test group after Coenzyme Q10 treatment in hippocampus. This study showed Coenzyme Q10 has protective effects in hippocampus after injury and it seems that Neuroprotective effects of Coenzyme Q10 in some neurodegenerative diseases com from that.

Keywords


  1. Bhagavan, H.N., Chopra R.K., Coenzyme Q10: Absorption, tissue uptake. Drug Metab Pharmacokinet J, 2006, Vol. 40(5), pp. 445–453.
  2. Beal, M.F., Mitochondrial Dysfunction and Oxidative Damage in Alzheimer’s and Parkinson’s Diseases and Coenzyme Q10 as a Potential Treatment. Bioenerg Biomembr J, 2004, Vol. 36, pp. 381-386.
  3. Lee, B., Lin, Y., Huang, Y., Ko, Y.W., Hsia, S., Lin, P.T., The Relationship between Coenzyme Q10, Oxidative Stress, and Antioxidant Enzymes Activities and Coronary Artery Disease. Sci World J, 2012, Vol. 2012, pp. 1-8.
  4. Kagan, V.E., Quinn, P.J., Coenzyme, Q., Molecular Mechanisms in Health and Disease. Modern Nutrition Series. 1 edit, CRC Press, 2000.
  5. Yang, X., Dai, G., Li, G., et al., Coenzyme Q10 Reduces β-Amyloid Plaque in an APP/PS1 Transgenic Mouse Model of Alzheimer’s Disease. Mol Neurosci J, 2010, Vol. 41, pp. 110–113.
  6. Berkovic, S.F., Mulley, J.C., Scheffer, I.E., Petrou, S., Human epilepsies: Interaction of genetic and environmental factors. Trends Neurosci, 2006, Vol. 29(7), pp. 391-397.
  7. Tsenga, K., Chambersb, R., Lipskac, B., The neonatal ventral hippocampal lesion as a heuristic neurodevelopmental model of schizophrenia. Behav Brain Res J, 2009, Vol. 204, pp. 295–305.
  8. Person, P., Robert, N., Trimethyltin-Induced Neurogenesis in the Murine Hippocampus. Neurotox Res J, 2004, Vol. 5(8), pp.  623–627.
  9. Jung, E., Lee, M., Ahn, Ch., The Neuroprotective Effect of Gugijihwang-Tang on Trimethyltin-Induced Memory Dysfunction in the Rat. Evid Based Complementary Altern J, 2013, Vol. 4, pp. 1-6. 
  10. Kalayci1, M., Unal, M., Gul, S., Effect of Coenzyme Q10 on ischemia and neuronal damage in an experimental traumatic brain-injury model in rats. BMC Neurosci, 2011, Vol. 12, pp. 1-7.