The Effect of Probiotics Supplements on Oxidative Stress in Various Diseases: A Systematic Review Study

Document Type : Review Article


Trauma Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran


Introduction: Recently, the consumption of probiotics to decrease oxidative stress has been recommended. We aimed to assess the effect of probiotics on oxidative stress in various diseases and as well as in different models in a systematic review study.
Methods: Articles searched through scientific sources such as PubMed, MEDLINE, Wiley, EMBASE, ISI Web of Knowledge and Scopus by two review authors independently. The keywords that applied to search these articles included: Probiotics, oxidative stress, Stresses, Oxidative and Stress. Then results combined and reviewed regarding the type of study, type of disease/participants and outcomes.
Results: We included 19 eligible studies. The results showed that various probiotics supplements could improvement oxidative stress parameters in women pregnant, patients with type 2 diabetics, Diabetic kidney disease type 2, gestational diabetes mellitus, aging process, Inflammatory factors in petrochemical workers, acute necrotizing pancreatitis, and polycystic ovary syndrome. But, no significant effect was reported on the oxidative status in patients with Rheumatoid Arthritis.
Conclusions: Probiotics supplements could improvement oxidative stress biomarkers in various diseases. There are still some controversies about these methods and types of probiotics supplementations. So, it is recommended that more studies should be conducted for a better decision.


Articles in Press, Accepted Manuscript
Available Online from 12 October 2020
  • Receive Date: 23 October 2019
  • Revise Date: 23 February 2020
  • Accept Date: 26 February 2020