Journal of Applied Biotechnology Reports

Journal of Applied Biotechnology Reports

Neuroprotective Effect of Coenzyme Q10 in Hippocampal Injury in Balb/c Mouse

Document Type : Original Article

Authors
Sara Rigi 1
Abolhassan Sakhaei 1
Azadeh Niknam Asl 2
Akram Alizadeh 2
Fatemeh Beigi 1
Mehdy Mehdizadeh 1
Majid Ketabi 3
Mansooreh Soleimani 4
1 Department of Anatomy, School of Medicine, Iran University of Medical Science, Tehran, Iran
2 Department of Tissue Engineering, Tehran University of Medical Science, Tehran, Iran
3 Stem Cell Research Center & Department of Anatomy, School of Medicine, Hormozgan University of Medical Science, Bandar Abbas, Iran
4 Cellular and Molecular Research Center & Department of Anatomy, School of Medicine, Tehran University of Medical Science, Tehran, Iran
Abstract
Coenzyme Q10 is a promising agent for neuroprotection in neurodegenerative diseases. Neuroprotective effects of Coenzyme Q10 demonstrated in some neurodegenerative diseases such as Parkinson, Alzheimer and etc. Hippocampus is home of these diseases. We assayed Coenzyme Q10 effects on Hippocampal injury model and our hypothesis is that Coenzyme Q10 has Neuroprotective effects in some neurodegenerative diseases via hippocampus. For this purpose 24 Balb/c mouse took in 4 groups: Control (Without any treatment), Vehicle (Treated with sesame oil as Coenzyme Q10 vehicle), Hyppocampal injury model (Treated with Trimethyltin chlorideneurotoxin, 2.5 mg per kg IP), and test (Treated with Coenzyme Q10 after Trimethyltin chloride injection, 10 mg per kg IP for 2 weeks). After two weeks brain harvested and hippocampus tissue assayed by Nissl and Tunnel staining. Hystological study showed significantly increase of normal cells and decrease of apoptotic cells in test group after Coenzyme Q10 treatment in hippocampus. This study showed Coenzyme Q10 has protective effects in hippocampus after injury and it seems that Neuroprotective effects of Coenzyme Q10 in some neurodegenerative diseases com from that.
Keywords
Coenzyme Q10
Neuroprotection
Trimethyltin Chloride
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Journal of Applied Biotechnology Reports
Volume 1, Issue 2
Spring 2014
Pages 55-58

  • Receive Date 02 April 2014
  • Revise Date 11 May 2014
  • Accept Date 10 May 2014