Strategies to Designing Chimeric Recombinant Vaccines

Mirhosseini, Seyed Ali; Taki, Elahe; Erfanimanesh, Soroor; Karami-Zarandi, Morteza; Jasemi, Seyede Somaye; Afrasiabi, Shima; Feyisa, Seifu; Rahdar, Hossein Ali; Rezaei, Mohamad Javad; Amani, Jafar

doi:10.30491/jabr.2020.192358.1072

Strategies to Designing Chimeric Recombinant Vaccines

Document Type : Review Article

Authors

Seyed Ali Mirhosseini ¹

Elahe Taki ²

Soroor Erfanimanesh ²

Morteza Karami-Zarandi ²

Seyede Somaye Jasemi ²

Shima Afrasiabi ²

Seifu Feyisa ²

Hossein Ali Rahdar ³

Mohamad Javad Rezaei ¹

Jafar Amani ¹

¹ Applied Microbiology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran

² Department of Microbiology, School of Medicine, Tehran University of Medical Science, Tehran, Iran

³ Department of Microbiology, Iranshahr University of Medical Science, Iranshahr, Iran

10.30491/jabr.2020.192358.1072

Abstract

With the advent and development of the science of immunology, molecular biology, microbiology, genetic and biochemistry, human beings embarked on vaccines and deployed them. Since the birth of vaccine by Edward Jenner, there has been great progress in the production of various vaccines against different pathogens and antigens. Due to increased infectious diseases and multi-drug resistant strains, one of the best ways to encounter them is through vaccination. There are various vaccines with some problems which are the result of various mechanisms for the escape of pathogenic microbes from the immune system. Therefore, there is a need for comprehensive vaccines that can provide extensive immune responses. Chimeric vaccines and recombinant chimeric vaccines are developing nowadays and can protect against different serovars. The first recombinant vaccine was introduced in the mid‑1970s against the hepatitis B virus (HBV). Recombinant chimeric proteins are developing nowadays that have the advantage of both recombinant and chimeric properties.

Keywords

Vaccines

Chimeric Vaccines

Recombinant Chimeric Vaccines

Hepatitis B