Antioxidant and Antidiabetic Effect of Capparis decidua Edgew (Forssk.) Extract on Liver and Pancreas of Streptozotocin-Induced Diabetic Rats

Ramzani Ghara, Abdollah; Ezzati Ghadi, Fereshteh; Hosseini, Seyed Hamzeh; Piacente, Sonia; Cerulli, Antonietta; Alizadeh, Akram; Mirmahmoudi, Rouhollah

doi:10.30491/jabr.2020.222547.1194

Antioxidant and Antidiabetic Effect of Capparis decidua Edgew (Forssk.) Extract on Liver and Pancreas of Streptozotocin-Induced Diabetic Rats

Document Type : Original Article

Authors

Abdollah Ramzani Ghara ¹

Fereshteh Ezzati Ghadi ¹

Seyed Hamzeh Hosseini ¹

Sonia Piacente ²

Antonietta Cerulli ²

Akram Alizadeh ³

Rouhollah Mirmahmoudi ⁴

¹ Department of Biology, Faculty of Science, University of Jiroft, Jiroft, Iran

² Department of Pharmacy, University of Salerno, Via Giovanni Paolo II 132, 84084 Fisciano, Salerno, Italy

³ Department of Tissue Engineering and Applied Cell Sciences, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran

⁴ Department of Animal Science, Faculty of Agriculture, University of Jiroft, Jiroft, Iran

10.30491/jabr.2020.222547.1194

Abstract

Introduction: The twig of Capparis decidua has been traditionally used as an antidiabetic agent but its medicinal use has not been scientifically proved yet. Present study evaluated the antidiabetic effect and antioxidant activities of aquatic extract of twigof Capparis decidua on liver and pancreas of diabetic rats induced by Streptozotocin (STZ).
Materials and Methods: The effect of Capparis decidua was evaluated by biochemical, histological and FTIR studies. All biochemical and biophysical parameters were estimated after 15 days of daily oral administrations of the aqueous extract.
Results: Results showed that oral use of Capparis decidua extract (250 mg/kg) caused significant reduction in the fasting blood glucose levels in diabetic rats when compared to control rats. Moreover, the altered level of lipid peroxidation, antioxidant, lipid profiles, liver enzymes, and also structural changes were reversed in STZ-induced diabetic rats which received Capparis decidua extract.
Conclusions: In conclusion, aqueous extract of Capparis decidua has potent antidiabetic and antioxidant activity.

Keywords

Capparis decidua

Antioxidant

Liver

Pancreas

Diabetes