Document Type: Original Article
Mobility Impairment Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
Department of Internal Medicine, School of Medicine, Babol University of Medical Sciences, Babol, Iran
Clinical Research Development Center, Ayatollah Rohani Hospital, Babol University of Medical Sciences, Babol, Iran
Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
Introduction: Serum uric acid (UA) level is reported to be associated with a variety of cardiometabolic risk factors. Although various studies have reported elevated levels of UA in patients with metabolic syndrome (MetS), its clinical interpretation is still controversial and challenging. Thus, we examined the association between hyperuricemia (HUA) and UA levels with MetS, its components and number of components.
Materials and Methods: This population-based cross-sectional study included 1561 older people who participated in Amirkola Health and Aging Project (AHAP) in North of Iran. MetS was defined based on the Iranian National Committee of Obesity criteria. Blood pressure, fasting blood glucose (FBG), lipid profiles, UA and anthropometric measures were determined.
Results: The diagnosis of the MetS was not associated with UA levels and HUA. The results of this study showed that the only FBG is a component which increases the risk of HUA.
Conclusions: Our findings from a community elderly population suggest that the UA levels and HUA were not associated with the diagnosis of the MetS by the stepwise logistic regression approach. However, in spite of various confounding factors, including metabolic and non-metabolic components in the association with MetS and UA, the whole relationship remains to be determined. A large prospective study is needed to reveal the clinical significance of UA in MetS.