Electrochemical Determination of Calcium Dobesilate on Graphene Glassy Carbon Modified Electrode

Document Type : Original Article


1 Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran

2 Institute of Biochemistry & Biophysics, University of Tehran, Iran

3 Department of Energy Engineering and Physics, Faculty of Physics, Amirkabir University of Technology, Tehran, Iran

4 Nanobiotechnology Research Center, Baqiyatallah University of Medical Science, Tehran, Iran


Graphene modified glassy carbon electrodes have been developed for the determination of calcium dobesilate in pharmaceutical formulations. The prepared graphene and CNTs were used as a conductive substrate for electrochemical study of calcium dobesilate. The direct electrochemistry of calcium dobesilate showed a reversible cyclic voltammogram with a formal potential of 133 mV (vs. Ag/AgCl) for graphene modified electrodes in 0.1 M phosphate buffer. The linear concentration range of the sensor is 30-120 ng/mL for graphene modified electrode, respectively. The lifetime of biosensor is more than 2 weeks. The proposed modified electrode provides a new promising and alternative way to detect calcium dobesilate


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