Taherian, A., Jahangiri, A., Namjoyan, F., Hajhosseini, S. (2014). The Inhibition Effects of Two Species of Astragalus Extracts on Mushroom Tyrosinase Activity. Journal of Applied Biotechnology Reports, 1(2), 63-66.
Azadeh Taherian; Alireza Jahangiri; Forogh Namjoyan; Seyed Reza Hajhosseini. "The Inhibition Effects of Two Species of Astragalus Extracts on Mushroom Tyrosinase Activity". Journal of Applied Biotechnology Reports, 1, 2, 2014, 63-66.
Taherian, A., Jahangiri, A., Namjoyan, F., Hajhosseini, S. (2014). 'The Inhibition Effects of Two Species of Astragalus Extracts on Mushroom Tyrosinase Activity', Journal of Applied Biotechnology Reports, 1(2), pp. 63-66.
Taherian, A., Jahangiri, A., Namjoyan, F., Hajhosseini, S. The Inhibition Effects of Two Species of Astragalus Extracts on Mushroom Tyrosinase Activity. Journal of Applied Biotechnology Reports, 2014; 1(2): 63-66.
The Inhibition Effects of Two Species of Astragalus Extracts on Mushroom Tyrosinase Activity
1Department of Biology, School of Science and Agriculture, Payame Noor University of Tehran, Tehran, Iran
2Department of Medicinal Chemistry, School of Pharmacy, Ahwaz Jundishapur University of Medical Sciences, Ahwaz, Iran
3Department of Pharmacognosy, School of Pharmacy, Ahwaz Jundishapur University of Medical Sciences, Ahwaz, Iran
Receive Date: 25 March 2014,
Revise Date: 10 May 2014,
Accept Date: 10 May 2014
Abstract
Melanin pigment plays a critical role in camouflage and protection against harmful effects of solar radiation. Melanogenesis is under complex regulatory control by multiple agents. Tyrosinase is a multifunctional, which catalyzes the first two steps in mammalian melanogenesis. In this study, inhibitory effects of Astragalus fasciculifolius and Astragalus gypsicolus on diphenolase activity of mushroom tyrosinase were evaluated. .Ethanol 80% extracts were prepared for screening tests. The IC50, Ki, Km and Vm values of Astragalus fasciculifolius and Astragalus gypsicolus were measured then compared them. We found that Both extracts show mixed type inhibition on mushroom tyrosinase when L-DOPA was used as a substrate.
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