Baqiyatallah University of Medical Sciences Journal of Applied Biotechnology Reports 2322-1186 13 1 2026 03 30 Cellular Receptors and their Associated Factors for SARS-CoV-2 Entry Designing Susceptible Cells: A review 1889 1898 242571 10.30491/jabr.2025.518549.1868 EN Seyed Kiarash Aghayan Applied Virology Research Center, Biomedicine Technologies Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran 0000-0002-8165-1344 Mohammad Reza Heydari Department of Veterinary Medicine, Shabestar Branch, Islamic Azad University, Shabestar, Iran 0009-0003-4837-4298 Amir Yousefkhany Department of Veterinary Medicine, Shabestar Branch, Islamic Azad University, Shabestar, Iran Yousef Tarvedizadeh Biology Research Center, Faculty of Basic Sciences, Imam Hussein University, Tehran, Iran Majid Mirzaei Nodooshan Applied Virology Research Center, Biomedicine Technologies Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran 0000-0002-8180-1031 Ali Salimi Jeda Applied Virology Research Center, Biomedicine Technologies Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran 0000-0003-3197-9509 Hadi Esmaeili Gouvarchin Ghaleh Applied Virology Research Center, Biomedicine Technologies Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran 0000-0001-8562-2295 Mostafa Eslami Mahmoudabadi Students Research Committee, Baqiyatallah University of Medical Sciences, Tehran, Iran 0009-0005-1568-5393 Journal Article 2025 04 22 <span class="fontstyle0">SARS-CoV-2, the causative agent of COVID-19, emerged in late 2019 and rapidly evolved into a significant global health crisis, impacting millions of individuals worldwide. Like other respiratory viruses, SARS-CoV-2 depends on specific cellular receptors to infiltrate host cells and initiate the infection process. To effectively combat this virus, it is essential to thoroughly understand the intricate interactions between viral attachment factors and these cellular receptors. This analysis explores the various cellular receptors involved in the infection process of SARS-CoV-2 and examines the complex interactions between the virus and its host cells. We emphasize the critical components that facilitate the virus's entry into host cells and consider potential strategies to modify receptor expression, thereby enhancing susceptibility to infection. Gaining insights into these receptors and their associated components is vital for developing effective animal models, which can significantly aid in research efforts. Ultimately, this understanding will contribute to the creation of targeted therapeutic interventions and preventive measures against COVID-19 and similar viral infections.</span>  https://www.biotechrep.ir/article_242571_a096079c65bf5d712d379d3362e89dfd.pdf