Baqiyatallah University of Medical Sciences Journal of Applied Biotechnology Reports 2322-1186 12 2 2025 06 01 Regulatory Interplay of Long Non-Coding RNAs in Breast Cancer Progression 1594 1612 225672 10.30491/jabr.2024.470488.1762 EN Vibhushini R Department of Biotechnology, Sri Venkateswara College of Engineering, Post Bag No.1, Sriperumbudur Taluk - 602117, Kancheepuram, Tamil Nadu, India Jyothishree Veerabhadran Department of Biotechnology, Sri Venkateswara College of Engineering, Post Bag No.1, Sriperumbudur Taluk - 602117, Kancheepuram, Tamil Nadu, India 0009-0001-6099-2182 Nalinkanth Veerabadran Ghone Department of Chemical Engineering, Sri Sivasubramaniya Nadar College of Engineering, Rajiv Gandhi Salai (OMR), Kalavakkam - 603110, Tamil Nadu, India 0000-0002-0968-4790 Hariharan Jayaraman Department of Biotechnology, Sri Venkateswara College of Engineering, Post Bag No.1, Sriperumbudur Taluk - 602117, Kancheepuram, Tamil Nadu, India 0000-0002-2545-4661 Journal Article 2024 07 29 <span class="fontstyle0">Globally, breast cancer is a severe and diverse disease with a high morbidity and death rate. Recent studies have highlighted the critical role of long non-coding RNAs (lncRNAs) play in the initiation and spread of breast cancer. lncRNAs are crucial regulators of gene expression and are implicated in various cellular processes, including tumorigenesis. The dysregulation of lncRNAs has been linked to aberrant cell proliferation in breast cancer. By modulating gene expression at transcriptional and post-transcriptional levels, lncRNAs can promote or suppress cell proliferation, influencing tumor growth and progression. lncRNAs can control the invasion and migration of breast cancer cells, thereby promoting the spread of metastatic cancer to other organs, through interactions with miRNAs and other molecular pathways. Understanding the intricate mechanisms by which lncRNAs contribute to these processes is essential for developing targeted therapies and improving patient outcomes. The crosstalk between lncRNAs and other intracellular proteins is important for understanding their functional roles in breast cancer progression. Protein interactions influence the stability, activity, and localization of lncRNAs, which in turn influences how these RNAs affect cellular processes. This review investigates the complex interactions of lncRNAs with miRNAs and proteins in breast cancer, with a focus on their roles in metastasis, proliferation, and other stages of the disease's progression. Moreover, with the ability to target specific genes, identifying novel biomarkers, therapeutic targets and potential in overcoming drug resistance lncRNAs represent an exciting area in RNA-based therapies and have the potential to transform breast cancer treatment.</span>  https://www.biotechrep.ir/article_225672_57db8f810f92fa2da22b87730a0afbf8.pdf