Baqiyatallah University of Medical Sciences Journal of Applied Biotechnology Reports 2322-1186 8 4 2021 12 01 A Review on the Applications of Listex™ P100 Bacteriophage 332 336 142529 10.30491/jabr.2020.248851.1286 EN Behzad Heshmati Applied Virology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran 0000-0002-7673-9376 Hadi Esmaeili Gouvarchin Galeh Applied Virology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran 0000-0001-8562-2295 Ruhollah Dorostkar Applied Virology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran 0000-0002-2574-1150 Journal Article 2020 09 19 Listeria monocytogenes is a Gram-positive, small rod-shaped bacterium that causes listeriosis in animals and humans from eating contaminated food. It can mostly affect susceptible individuals with defective immune systems. Also, the mortality rates, as a result of listeriosis, can be varied between 30 to 75%. Listeria had been reported to be more allergic to antibiotics than Gram-positive bacteria. However, according to reports, Listeria has recently been allergic to the resistance to these antibiotics. Such an increase in antibiotic resistance in Listeria is in line with the worldwide pattern of the increasing prevalence of antibiotic resistance, including multiple antibiotic resistance in many bacterial groups. Therefore, one of the ways to reduce the incidence of this disease in animals and humans is the biological control of this bacterium by bacteriophage. Bacteriophages have been shown to be effective in controlling L. monocytogenes in food. In 2006, the US Food and Drug Administration approved the preparation of two bacteriophages (Listex™ P100 and LMP-102) for use in certain foods to control L. monocytogenes. The prevalence of foodborne pathogens is the use of phages as biocontrol agents in food. Also, the activation of Phage Listex™ P100 against multiple L. monocytogenes serovars allows it to kill L. monocytogenes and its immunogenicity in food and clinical products. The prevalence of foodborne pathogens is the use of phages as biocontrol agents in food. Also, the activation of Phage Listex™ P100 against multiple L. monocytogenes serovars allows it to kill L. monocytogenes and its immunogenicity in food and clinical products.

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