Baqiyatallah University of Medical Sciences Journal of Applied Biotechnology Reports 2322-1186 8 4 2021 12 01 The Effect of Probiotics Supplements on Oxidative Stress in Various Diseases: A Systematic Review Study 326 331 117863 10.30491/jabr.2020.117863 EN Sadrollah Mahmoudi Trauma Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran 0000-0001-5251-3949 Mohammad Reza Ghane Trauma Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran Mehrdad Faraji Trauma Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran Hassan Goodarzi Trauma Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran 0000-0002-8640-6639 Fahimeh Shahjooie Trauma Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran Hamid Reza Javadzadeh Trauma Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran Journal Article 2019 10 23 <span class="fontstyle0"><strong>Introduction:</strong> </span><span class="fontstyle2">Recently, the consumption of probiotics to decrease Oxidative Stress (OS) has been recommended. The present study aimed to assess the effect of probiotics on OS in various diseases as well as in different models in a systematic review study.<br /></span><span class="fontstyle0"><strong>Materials and Methods:</strong> </span><span class="fontstyle2">Articles were searched through scientific sources such as PubMed, MEDLINE, Wiley, EMBASE, ISI Web of Knowledge, and Scopus by two review authors independently. The keywords that applied to search these articles included: Probiotics, OS, Stresses, Oxidative, and Stress. Results were then combined and reviewed regarding the type of study, type of disease/participants, and outcomes.<br /></span><span class="fontstyle0"><strong>Results:</strong> </span><span class="fontstyle2">In order to conduct this study, 19 eligible studies were investigated. The results showed that various probiotics supplements could improve OS parameters in pregnant women, patients with type 2 diabetics, Diabetic Kidney Disease (DKD) type 2, gestational diabetes mellitus, and the aging process, inflammatory factors in petrochemical workers, acute necrotizing pancreatitis, and polycystic ovary syndrome. However, no significant effect was reported on the oxidative status in patients with Rheumatoid Arthritis.<br /></span><span class="fontstyle0"><strong>Conclusions:</strong> </span><span class="fontstyle2">Probiotics supplements could improve OS biomarkers in various diseases. There are still some controversies about these methods and types of probiotics supplementations. It is recommended that more studies should be conducted for a better decision.</span>  https://www.biotechrep.ir/article_117863_508e4e8b389fde63821619ba59f7cab3.pdf