TY - JOUR ID - 69195 TI - Therapeutic Potential of Glucose Regulated Protein 78 in Cancer JO - Journal of Applied Biotechnology Reports JA - JABR LA - en SN - 2322-1186 AU - Aghamollaei, Hosssein AU - Mousavi Gargari, Seyed Latif AU - Ghanei, Mostafa AD - Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran AD - Department of Biology, Faculty of Basic Science, Shahed University, Tehran Iran AD - Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran Y1 - 2015 PY - 2015 VL - 2 IS - 4 SP - 305 EP - 310 KW - GRP78 KW - Biological Function KW - cancer KW - Tumor DO - N2 - Endoplasmic reticulum has a critical role in the synthesis and folding of secretory and membrane proteins. High accumulation of proteins in ER activates the unfolded protein response and glucose regulated protein 78 or GPR78 plays an essential role in this pathway.  Unfolded protein response is activated in cancerous cells due to their adverse condition to survive and it has been shown that GRP78 can be expressed in tumor cell membrane. Overexpresion and localization of GRP78 makes it a suitable target for the treatment of cancer. This review describes cellular localization, biological function, and role of GRP78 in cancer induction. Methods for tumor inhibition via GRP78 are also discussed. UR - https://www.biotechrep.ir/article_69195.html L1 - https://www.biotechrep.ir/article_69195_953e78cc29570628a9fba31a0d35ebfd.pdf ER -