TY - JOUR ID - 69184 TI - Mechanisms and Performances of Adjuvants in Vaccine Immunogenicity JO - Journal of Applied Biotechnology Reports JA - JABR LA - en SN - 2322-1186 AU - Gheibihayat, Seyed Mohammad AU - Sadeghinia, Azam AU - Nazarian, Shahram AU - Adeli, Zahra AD - Young Researchers and Elite Club, Andimeshk Branch, Islamic Azad University, Andimeshk, Iran AD - Department of Cardiology, Faculty of Medicine, Dezful University of Medical Sciences, Dezful, Iran AD - Department of Biology, Faculty of Science, Imam-Hossein University, Tehran, Iran AD - Department of Microbiology, Islamic Azad University, Damghan Branch, Damghan, Iran Y1 - 2015 PY - 2015 VL - 2 IS - 3 SP - 257 EP - 264 KW - Adjuvants KW - Vaccine KW - Immunostimulating Complexe KW - Alum KW - MHC DO - N2 - An adjuvant is a substance that is added to a vaccine to increase the body's immune response to the vaccine. Vaccines containing adjuvants are tested for safety in clinical trials before they are licensed for use. The basic action of adjuvants is stimulating adaptive immune responses. Adjuvants recently licensed for human utilization involve alum squalane oil or water emulsion, influenza virosomes, and few cytokines as IFN-γ and IL-2. Some adjuvants are currently under investigation such as DNA motifs, monophosphoryl lipid A, Cholera Toxin, E. coli heat Labile Toxin, Saponins, Immunostimulating complexes, liposomes, Flt3 ligand as a pleotropic glycoprotein, non-ionic block copolymers. This paper is an overview of most commonly used adjuvants, adjuvant mechanisms, adjuvant formulations and adjuvant limitations. UR - https://www.biotechrep.ir/article_69184.html L1 - https://www.biotechrep.ir/article_69184_a6dac80c3f3c915731496bc70051cced.pdf ER -