TY - JOUR ID - 138077 TI - Strategies to Designing Chimeric Recombinant Vaccines JO - Journal of Applied Biotechnology Reports JA - JABR LA - en SN - 2322-1186 AU - Mirhosseini, Seyed Ali AU - Taki, Elahe AU - Erfanimanesh, Soroor AU - Karami-Zarandi, Morteza AU - Jasemi, Seyede Somaye AU - Afrasiabi, Shima AU - Feyisa, Seifu AU - Rahdar, Hossein Ali AU - Rezaei, Mohamad Javad AU - Amani, Jafar AD - Applied Microbiology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran AD - Department of Microbiology, School of Medicine, Tehran University of Medical Science, Tehran, Iran AD - Department of Microbiology, Iranshahr University of Medical Science, Iranshahr, Iran Y1 - 2021 PY - 2021 VL - 8 IS - 3 SP - 203 EP - 220 KW - Vaccines KW - Chimeric Vaccines KW - Recombinant Chimeric Vaccines KW - Hepatitis B DO - 10.30491/jabr.2020.192358.1072 N2 - With the advent and development of the science of immunology, molecular biology, microbiology, genetic and biochemistry, human beings embarked on vaccines and deployed them. Since the birth of vaccine by Edward Jenner, there has been great progress in the production of various vaccines against different pathogens and antigens. Due to increased infectious diseases and multi-drug resistant strains, one of the best ways to encounter them is through vaccination. There are various vaccines with some problems which are the result of various mechanisms for the escape of pathogenic microbes from the immune system. Therefore, there is a need for comprehensive vaccines that can provide extensive immune responses. Chimeric vaccines and recombinant chimeric vaccines are developing nowadays and can protect against different serovars. The first recombinant vaccine was introduced in the mid‑1970s against the hepatitis B virus (HBV). Recombinant chimeric proteins are developing nowadays that have the advantage of both recombinant and chimeric properties. UR - https://www.biotechrep.ir/article_138077.html L1 - https://www.biotechrep.ir/article_138077_c89530e931c31177905f13a7aad66d60.pdf ER -