@article { author = {Naghib, Maryam and Kariminik, Ashraf and Arababadi, Mahammad and Rokhbakhsh-Zamin, Farokh}, title = {The Effects of Royal Jelly on the Pro-Inflammatory Innate Immunity Cytokines in Patients Infected with Hepatitis B Virus and Its Antiviral Activity}, journal = {Journal of Applied Biotechnology Reports}, volume = {9}, number = {2}, pages = {640-644}, year = {2022}, publisher = {Baqiyatallah University of Medical Sciences}, issn = {2322-1186}, eissn = {2423-5784}, doi = {10.30491/jabr.2021.295464.1421}, abstract = {Introduction: Innate immunity cytokines conduct significant functions in the stimulation and induction of liver complications in Hepatitis B infected patients. It has been reported that Royal Jelly (RJ) has important roles in decreasing the pro-inflammatory cytokines in both in vitro and in vivo conditions. This project aimed to investigate the impacts of 1 month RJ administration on interleukin 1 beta (IL-1β), tumor necrosis factor-alpha (TNF-α), and interleukin 6 (IL-6) serum levels in the Hepatitis B patients.Materials and Methods: In this research, 30 Hepatitis B cases (patients) were entered in order to be under the treatment of RJ for 1 month. Before and after treatment with RJ, Hepatitis B Virus (HBV) copy numbers were evaluated using Real-Time PCR and IL-1β, TNF-α, and IL-6 serum levels were evaluated using the ELISA technique.Results: The RJ treatment significantly reduced the number of HBV-DNA copies and led to down-regulation of TNF-α and IL-6, which were not substantial. The IL-1β, TNF-α, and IL-6 serum levels were not changed after RJ treatment in both men and women.Conclusions: Based on the findings of the present study, it seems that RJ plays anti-viral and anti-inflammatory roles in the in vivo conditions in infected patients with HBV. }, keywords = {Royal Jelly,IL-1β,TNF-α,IL-6,Hepatitis B}, url = {https://www.biotechrep.ir/article_151847.html}, eprint = {https://www.biotechrep.ir/article_151847_6ba768728668a5e18936edfc9c4780d2.pdf} }