@article { author = {Zafari, Fariba and Sadeghi, Morteza}, title = {The Association Between Matrix Metalloproteinases-9-1562 C/T Polymorphism and Lung Cancer Susceptibility: A Systematic Review and Meta-Analysis}, journal = {Journal of Applied Biotechnology Reports}, volume = {8}, number = {1}, pages = {-}, year = {2021}, publisher = {Baqiyatallah University of Medical Sciences}, issn = {2322-1186}, eissn = {2423-5784}, doi = {10.30491/jabr.2021.128739}, abstract = {Introduction: Matrix metalloproteinases (MMPs) are a family of zinc-dependent proteinase. Several studies have reported the association between the single nucleotide polymorphisms(C/T) -1562 in the MMP-9 promoter and the risk of cancer. In this study, we decided to carry out a comprehensive meta-analysis to obtain a reasonable result about the association between this polymorphism and the risk of lung cancer. Materials and Methods: A complete literature review was conducted within the databases of ISI Web of Knowledge, google scholar, and PubMed for studies on lung cancer published from 2002 to 2018. A meta-analysis was conducted which included more than 3000 case and control subjects. The pooled Odds Ratio (OR) and 95% Confidence Intervals ( CI) were used for dominant, recessive, and co-dominant MMP-9 genotypes to assess the strength of the association. Results: Analysis indicated no significant association between MMP-9-1562C/T polymorphism and the risk of lung cancer, dominant model; [CT+TT/CC]: OR = 0.972, 95% CI = 0.811–1.164, recessive model [CC+CT/TT] OR= 1.027, 95% CI = 0.651–1.618 and co-dominant model [TT/CC] OR = 0.983, 95% CI = 0.550–1.755. Conclusions: No association was observed between the MMP9 -1562 C/T polymorphism and the incidence of lung cancer. The meta-analysis demonstrated that this polymorphism can't serve as a diagnostic marker for lung cancer.}, keywords = {MMP-9,Lung cancer,Polymorphism}, url = {https://www.biotechrep.ir/article_128739.html}, eprint = {https://www.biotechrep.ir/article_128739_25dc2b04167196c678df0e7902e8b335.pdf} }