@article { author = {Asghari, Asieh and Fazilati, Mohammad and Latifi, Ali Mohammad and Salavati, Hossain and Choopani, Ali}, title = {A Review on Antioxidant Properties of Spirulina}, journal = {Journal of Applied Biotechnology Reports}, volume = {3}, number = {1}, pages = {345-351}, year = {2016}, publisher = {Baqiyatallah University of Medical Sciences}, issn = {2322-1186}, eissn = {2423-5784}, doi = {}, abstract = {Spirulina is free-floating filamentous microalgae growing in alkaline water bodies. As early as over 400 years ago, Spirulina was eaten as food by the Mayas, Toltec’s and Kanembu in Mexico during the Aztec civilization. Spirulina is a well-known source of valuable food supplements, such as proteins, vitamins, amino acids, minerals, fatty acids, etc. It is widely used in human and animal nutrition, as well as in the cosmetic industry. Both in vivo and in vitro trials have shown effective and promising results in the treatment of certain cancers and allergies, anemia, hepatotoxicity, viral infection, vascular diseases, radiation protection, and obesity. The antioxidant activities of Spirulina were demonstrated in a large number of preclinical studies. Antioxidants in preventing many human diseases. Findings of this study showed Spirulina can be used as a source of antioxidants.}, keywords = {Spirulina,Microalgae,Antioxidant,Anticancer}, url = {https://www.biotechrep.ir/article_69007.html}, eprint = {https://www.biotechrep.ir/article_69007_cf87ec6a3acc0e69c330b2086d8ecdd0.pdf} } @article { author = {Rajab Beiki, Mahdieh and Yazdian, Fatemeh and Rasekh, Behnam and Rashedi, Hamid and Darzian Rostami, Arash}, title = {Effect of Metal Nanoparticles on Biological Denitrification Process: A Review}, journal = {Journal of Applied Biotechnology Reports}, volume = {3}, number = {1}, pages = {353-358}, year = {2016}, publisher = {Baqiyatallah University of Medical Sciences}, issn = {2322-1186}, eissn = {2423-5784}, doi = {}, abstract = {Globally, increasing nitrate concentrations have become a serious environmental problem and a potential risk to public health. The World Health Organization (WHO) has set a limit of (10 mg/ (L)) NO3- for human consumption and (100 mg/ (L)) NO3- for animals. Water above these limits requires denitrification. Nitrate causes cancer, blue-baby syndrome, hypertension and thyroid hypertrophy. Several treatment processes can remove nitrates from water with varying degrees of efficiency, cost, and ease of operation. Among these processes chemical denitrification and biological denitrification are useful processes considering efficiency cost and maintenance. Denitrifying microorganisms are able to reduce nitrate to innocuous nitrogen gas using suitable source of electron. Oxides of metal nanoparticles, hydrogen gas, and sulfur reduced compounds; pyrite and arsenate have been used as electron donors for biological nitrate reduction. Among these electron donors H2 and oxides of metal nanoparticles have better performance in the removal of nitrate. Bio-denitrification coupled to metal nanoparticle oxidation is an inexpensive and advantageous process for nitrate removal from source of water. In this review article the biological denitrification efficiency was studied between free cell and cell amended metal nanoparticle such as nano scale zero valent iron (nZVI). This study investigated the potential applicability of employing metal nanoparticle as source of electron for biological nitrate reduction. Temperature, pH, nitrate concentration and dissolve oxygen concentration are the major factors affecting nitrate removal, with or without the presence of metal nanoparticles that studied in this article.}, keywords = {Water,Biological Denitrification,Metal Nanoparticles,Nano Scale Zero Valent Iron}, url = {https://www.biotechrep.ir/article_69008.html}, eprint = {https://www.biotechrep.ir/article_69008_f9cb9619874dec2b2779e47bcca93e31.pdf} } @article { author = {Dalvand, Mohamad and Soleimani Pari, Mohamad Javad and Zafari, Dostmorad and Roohparvar, Ramin and Tabib Ghafari, Seyed Mahmoud}, title = {Study on Virulence Factors of Mycosphaerella graminicola, the Causal Agent of Septoria Leaf Blotch and Reactions of Some Iranian Wheat Genotypes to this Pathogen in Iran}, journal = {Journal of Applied Biotechnology Reports}, volume = {3}, number = {1}, pages = {359-363}, year = {2016}, publisher = {Baqiyatallah University of Medical Sciences}, issn = {2322-1186}, eissn = {2423-5784}, doi = {}, abstract = {Septoria leaf blotch disease caused by Mycosphaerella graminicola is one of the most important diseases of wheat in Iran and around the world. Evaluation the reaction of wheat genotypes as well as identifying pathogen virulence factors is required in order to achieve a successful breeding program. The aim of this study was to assess the adult plant responses of Iranian bread wheat and durum wheat genotypes (developed by Iranian seed) Septoria tritici leaf blotch. Furthermore, this study has aimed surveying the virulence factors of this pathogen in warm and humid weather conditions of the south of Iran. Thus, the study was conducted in one of southern provinces of Iran, Khuzestan, for two sequential years (December 2013-May 2014 and December 2014-May 2015) and included 47 commercial varieties and 26 differential lines with a local pathogen isolate that was collected on a bread wheat variety. Data records were performed with a modified Saari and Prescott method in double-digit scale of 00–99. According to the results, from all commercial varieties, 5 varieties were resistant. Surprisingly, the durum varieties like Behrang and Karkhe were susceptible too. Based on the results of differentia-tion tests showed that the pathogen isolate of this region has virulence reaction against stb2, stb3, stb4, stb6, stb7, stb8, stb9, stb10, stb12, stb13, stb14, and stb18 genes and avirulence reaction against stb1, stb5, stb11, stb15, stb16, and stb17 genes.}, keywords = {Mycosphaerella graminicola,Virulence factors,Iranian Wheat}, url = {https://www.biotechrep.ir/article_69009.html}, eprint = {https://www.biotechrep.ir/article_69009_034a11e4e0bb2b27a0da5c03d1097ab9.pdf} } @article { author = {Pourabdollah, Kiana and Latifi, Ali Mohammad and Golzar, Hossein and Garshasbi, Morteza}, title = {Numerical Analysis of Temperature-Sensitive Hydrogels for Controlled Drug Release}, journal = {Journal of Applied Biotechnology Reports}, volume = {3}, number = {1}, pages = {365-372}, year = {2016}, publisher = {Baqiyatallah University of Medical Sciences}, issn = {2322-1186}, eissn = {2423-5784}, doi = {}, abstract = {Today hydrogels are considered as the materials that are able to play important role in drug delivery systems. To design an effective hydrogel applicable network, mathematical modeling has a critical role. A successful drug delivery device relies not only on intelligent network design but also on accurate prior mathematical modeling of drug release profiles. In this study, the modeling of the inflation behavior of temperature-sensitive hydrogel has been done by providing a mathematical model according to the thermodynamics and kinetics of the temperature-sensitive gel and also considering the heat transfer into the hydrogels during the inflation. The proposed model has been investigated numerically. The comparison between numerical and experimental results shows perfectly success in integrating equations of inflation thermodynamics and kinetics for modeling the inflation behavior of temperature-sensitive hydrogels that provide a new step in the modeling of such systems.}, keywords = {Hydrogel,Mathematical Modeling,Drug Delivery,Temperature-Sensitive}, url = {https://www.biotechrep.ir/article_69013.html}, eprint = {https://www.biotechrep.ir/article_69013_eb0988006af89a9d458e9d3902f8b6f2.pdf} } @article { author = {Iman, Maryam and Dashtestani, Fariba and Zafari, Zahra and Kamali, Mehdi and Ramezani, Manizheh and Eskandari, Khadijeh}, title = {Electrochemical Determination of Calcium Dobesilate on Graphene Glassy Carbon Modified Electrode}, journal = {Journal of Applied Biotechnology Reports}, volume = {3}, number = {1}, pages = {373-375}, year = {2016}, publisher = {Baqiyatallah University of Medical Sciences}, issn = {2322-1186}, eissn = {2423-5784}, doi = {}, abstract = {Graphene modified glassy carbon electrodes have been developed for the determination of calcium dobesilate in pharmaceutical formulations. The prepared graphene and CNTs were used as a conductive substrate for electrochemical study of calcium dobesilate. The direct electrochemistry of calcium dobesilate showed a reversible cyclic voltammogram with a formal potential of 133 mV (vs. Ag/AgCl) for graphene modified electrodes in 0.1 M phosphate buffer. The linear concentration range of the sensor is 30-120 ng/mL for graphene modified electrode, respectively. The lifetime of biosensor is more than 2 weeks. The proposed modified electrode provides a new promising and alternative way to detect calcium dobesilate}, keywords = {graphene,Sensor,Direct Electrochemistry,Calcium Dobesilate}, url = {https://www.biotechrep.ir/article_69014.html}, eprint = {https://www.biotechrep.ir/article_69014_d38a057193a90fd23cb379280bcc4a7a.pdf} } @article { author = {Soltani, Neda and Latifi, Ali Mohammad and Alnajar, Naba and Dezfulian, Mehrouz and Shokarvi, Shadman and Heydari, Mohammad and Choopani, Ali}, title = {Biochemical and Physiological Characterization of Tree Microalgae spp. as Candidates for Food Supplement}, journal = {Journal of Applied Biotechnology Reports}, volume = {3}, number = {1}, pages = {377-381}, year = {2016}, publisher = {Baqiyatallah University of Medical Sciences}, issn = {2322-1186}, eissn = {2423-5784}, doi = {}, abstract = {With increasing world populations, production of cost-effective and proper nourishment sources that can rapidly produce large amounts of nutritional value are needed. Microalgae are publicly used as nutrient supplement. In this research a screening of endemic potent microalgae was carried out. Chlorella, Scenedesmus and Spirulina sp. were isolated and purified and cultivated in liquid proper medium. Regarding to this, amino acid and fatty acid profiles, biochemical characters, antioxidant and antimicrobial and anticancer properties of experimented microalgae were evaluated by HPLC, GC, spectrophotometry, DPPH, MIC and MTT Assay respectively. The results showed highest content of total protein in Spirulina sp.1 (46.08 ppm) and total carbohydrates in Chlorella sp. (48.01 ppm). Antioxidant content was detected in mentioned microalgae. Cytotoxic effect of aqueousextract on L929 cells showed 10 mg/mL had highest effect on these cells. According to the results, Chlorella spp. and Spirulina spp.1 are better candidates for food supplement.}, keywords = {Bioactive Metabolites,Carbohydrate,Microalgae,Nourishment,Protein}, url = {https://www.biotechrep.ir/article_69015.html}, eprint = {https://www.biotechrep.ir/article_69015_85e9e6be223b29cc6b3801cd1012844f.pdf} } @article { author = {Abadian, Khadige and Keshavarz, Zohre and Mojab, Faraz and Alavi Majd, Hamid and Abbasi Nazari, Mohamad}, title = {The Effect of Teucrium Polium on the pain duration of Dysmenorrhea, The Placebo Controlled Randomized Clinical Trial}, journal = {Journal of Applied Biotechnology Reports}, volume = {3}, number = {1}, pages = {383-386}, year = {2016}, publisher = {Baqiyatallah University of Medical Sciences}, issn = {2322-1186}, eissn = {2423-5784}, doi = {}, abstract = {Primary dysmenorrhea is a prevalent problem and its effects decrease the quality of life in many women across the world. Due to the side-effects of synthetic drugs, there is an increasing trend toward herbal medicine. The aim of this study was to research the effect of Teucrium Polium compared to placebo on the pain duration of Dysmenorrhea. This triple-blind, randomized, clinical trial study was performed on 70 single female students between 20 and 30 years old educating in Shahid Beheshti University (Tehran, Iran) from October 2014 to February2014 .They were allocated randomly into two groups: In Teucrium Polium group (n =35) who took 250 mg of Teucrium Polium   powder q6h for the first 3 days of menstruation for two cycles. The second group (pelacebo) (n=35) received 250 mg starch powder. The pain duration of Dysmenorrhea was determined by visual analog scale (VAS) and questionnaire related to the pain duration. Based on results, there were no differences between two groups for demographic or descriptive variables. Comprising the pain duration showed that the participants in Teucrium Polium groups had lower significant pain in the 1st and the 2nd months after the treatment (P < 0.001) but in pelacebo group, there was not any significant decrease in the pain duration. No side effects were reported in the Teucrium Polium and pelacebo groups. Results showed that Teucrium Polium can be effective in decreasing the pain duration in primary dysmenorrhea.}, keywords = {Teucrium Polium,Pain Duration,Dysmenorrhea,Pelacebo}, url = {https://www.biotechrep.ir/article_69016.html}, eprint = {https://www.biotechrep.ir/article_69016_cd74ae50d080e09433a4afae589f10c2.pdf} }