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0.98). For other two models (R2 <0.9) occurred. The best fit for the pre balance core and a slow start model was occurred in n = 2. These results could indicate that the core is formed by connecting two reteplase monomers together. The reaction rate constants were calculated too. The results showed that increasing the temperature increases the reaction rate constant. With increasing temperature from 25 ˚C up to 70˚C, both of K1 and K2 increased from 4.7±0.1*10-11K1(min-1) to 1.6±0.2*10-7K1(min-1) and from 1.04±0.2*10-5 K2(M -1 min-1) to 1.5± 0.3*10-4 K2(M -1min-1), respectively for autocatalytic model. Limitation step of the reaction is the nucleation. K1
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